一项对多基因分数和认知功能下降的纵向研究,考虑到中老年和老年美国成年人的基线认知功能,生活方式行为和糖尿病
Tingting Liu1, Changwei Li2, Ruiyuan Zhang3
1College of Nursing, Florida State University, Tallahassee, FL, 32306, USA.
Alzheimer's research & therapy
|November 11, 2023
概括
一般认知的多基因分数预测了不同种族的认知衰退率. 身体活动可以减轻糖尿病患者认知能力下降的遗传风险.
科学领域:
- 遗传学 遗传学是一种遗传学.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 认知能力下降是一个越来越令人担忧的问题,特别是在老年人群中.
- 关于影响认知衰退的基因组因素的研究有限,特别是在考虑基线认知和生活方式时.
- 糖尿病患者患有认知障碍的风险更高,需要有针对性的研究.
研究的目的:
- 调查多基因评分对一般认知对认知衰退率的影响.
- 在一般人群和糖尿病患者中检查这些关联.
- 评估基线认知和生活方式行为对认知衰退的遗传预测的影响.
主要方法:
- 在健康和退休研究 (HRS) 中利用了来自12,090名白人和3,100名黑人参与者的数据.
- 在8年的随访期间,分析了认知指标 (单词回忆,精神状态,总认知得分) 的年变化率.
- 根据基线生活方式行为,APOE状态和先前的认知评估进行调整,并根据种族分层分析.
主要成果:
- 多基因分数显著预测了所有认知指标的年度变化,独立于生活方式和APOE状态.
- 在白人参与者中,多基因分数解释了认知衰退率 (高达29.9%) 的实质性差异.
- 在糖尿病患者中,身体活动被发现可以抵消精神状态和总认知分数的认知衰退的遗传易感性.
结论:
- 多基因分数是认知变化的有价值预测指标,提供了超越传统认知评估的见解.
- 生活方式因素,如体力活动,可以改变对认知能力下降的遗传倾向,特别是在患有糖尿病等风险人群中.
更多相关视频
相关概念视频
01:30Cognitive Development During Adulthood
122
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
122
02:20Longitudinal Research
12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K
01:26Longitudinal Studies
171
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
171
01:18Polygenic Traits
65.9K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
65.9K
01:28Human Genetics
587
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
587
01:30Biological Influences on Intelligence
120
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
120