患有风湿性疾病的儿童和青少年结核病 - 病例系列
Lenita de Melo Lima1, Adriana Rodrigues Fonseca2,3, Clemax Couto Sant'Anna2
1Pediatric Pulmonology Unit, Instituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro (UFRJ), Rua Bruno Lobo, 50 - Cidade Universitária, Rio de Janeiro, Brazil. nitamelo.le@gmail.com.
Pediatric rheumatology online journal
|November 11, 2023
概括
接受免疫抑制剂的类风湿性疾病 (RD) 的儿童患结核病 (TB) 的风险更高. 在这些易受伤害的儿科患者中,对结核病的早期怀疑和调查至关重要,特别是在像巴西这样的高发病率国家.
科学领域:
- 儿科 儿科 儿科
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 风湿性疾病 (RD) 增加了患者的结核病 (TB) 风险.
- 用免疫抑制剂/免疫生物学药物治疗的儿科RD患者是结核病的脆弱群体.
- 这项研究描述了在参考中心的儿童和青少年患有RD的结核病例.
研究的目的:
- 描述患有风湿性疾病和结核病并发的儿科患者的临床特征.
- 突出结核病查在免疫抑制RD患者的重要性.
- 在高结核病发病率的环境中为管理策略提供信息.
主要方法:
- 对患有RD的儿科结核病患者进行了回顾性病例系列分析.
- 从巴西里约热内卢的一个参考中心收集的数据 (1995-2022).
- 纳入标准:儿童/青少年被诊断患有RD和TB.
主要成果:
- 包括15名患者 (8名女性,结核病诊断时的平均年龄为9.81岁).
- 肺结核 (PTB) 主导 (9/15例);肺外结核发生在6名患者中.
- 常见的RD包括青少年异常性关节炎 (9) 和红性狼 (3);甲状腺素是最常见的免疫抑制剂.
结论:
- 在使用免疫抑制剂/免疫生物药物的儿科RD患者中,必须怀疑和调查结核病.
- 及时诊断和管理至关重要,特别是在像巴西这样的高结核病负担的国家.
- 这一病例系列强调了在这种特定患者群体中需要保持警.
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