精神分裂症和糖尿病前期或糖尿病患者的认知缺陷
Alexander Panickacheril John1,2, Thynn Mya1, Darren Haywood3,4,5,6
1University of Western Australia, Perth, Australia.
Acta psychiatrica Scandinavica
|November 11, 2023
概括
在患有2型糖尿病 (T2DM) 或糖尿病前期 (PD) 的精神分裂症患者中,认知缺陷比正常血糖患者更严重. T2DM显示对认知功能的影响最为显著.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症和2型糖尿病 (T2DM) 独立地与认知障碍有关.
- 对T2DM或糖尿病前期 (PD) 对精神分裂症患者认知的综合影响的研究不足.
研究的目的:
- 评估和比较精神分裂症患者的认知功能与正常血糖,PD和T2DM.
主要方法:
- 对187名精神分裂症或精神分裂情绪障碍患者的回顾性分析.
- 使用精神分裂症认知简要评估 (BACS) 评估认知功能.
- 统计分析包括参数和非参数测试.
主要成果:
- 观察到认知缺陷的梯度:在PD中轻度,在T2DM中严重,与正常血糖组相比.
- T2DM组的BACS复合分数明显低于PD (p=0.026) 和正常组 (p<0.001).
- 在大多数BACS子测试中,T2DM患者的得分较低,除了记忆,并且代币运动任务性能明显降低 (p<0.001).
结论:
- 精神分裂症患者患有失糖症,特别是T2DM,表现出更明显的认知缺陷.
- 认知障碍的严重程度随着血糖失调的程度而增加.
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