严重的急性疹与血中D-二聚合物水平升高有关
Lele Chen1, Qiuyang Xu1, Jingjing Liu1
1Department of Dermatology and Venereology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
The Journal of dermatology
|November 11, 2023
概括
升高的D-二聚物水平可能表明严重的急性疹 (AU). 较高的D-二次数与较高的C-反应蛋白和乳酸脱酶相关,表明需要使用葡萄糖皮质体和抗生素进行更积极的治疗.
科学领域:
- 皮肤病学 皮肤病学
- 血液学 血液学 血液学
- 临床化学 临床化学
背景情况:
- 准确评估急性疹 (AU) 严重程度对于有效的患者管理至关重要.
- 目前,缺乏可靠的生物标志物来评估AU的严重程度.
- 最初的观察表明,严重的AU与血D-二次体水平升高之间存在联系.
研究的目的:
- 为了研究严重AU患者的D-二次体水平升高.
- 在严重的AU中探索D-二聚合物水平和临床/实验室参数之间的关系.
- 为了确定D-二次体是否可以作为AU严重性和指导治疗的标记.
主要方法:
- 对139名患有严重AU的住院患者的临床实验室数据的回顾性分析.
- 从电子医疗记录中收集数据.
- 统计分析包括单变数和多变数回归,以评估D-二元体,C-反应蛋白 (CRP),乳酸脱酶 (LDH) 和其他临床因素之间的相关性.
主要成果:
- 在139名患者中,有117名患者 (84%) 呈现出血D-二聚合物水平升高.
- 提升的D-二次体组显示女性的患病率更高,年龄更小,发烧,和更短的医院前时间.
- D-二元水平与中性粒细胞百分比,CRP和LDH正相关;与医院前时间负相关.
- 需要抗生素和较高剂量的葡萄糖皮质类药物 (GCs) 的患者表现出较高的D-二聚物水平.
结论:
- 高血D-二聚合物水平在严重的AU中很常见,与炎症标志物 (CRP,LDH) 相相关.
- D-二聚体可以作为一个有价值的生物标志物来评估AU的严重程度.
- 较高的D-二聚物水平表明可能需要加强治疗,包括更高剂量的GC和抗生素.
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