在阿尔茨海默氏病的亚临床型活动和睡眠障碍
Astrid Devulder1, Jaiver Macea1, Alexandros Kalkanis2
1Laboratory for Epilepsy Research, KU Leuven and Department of Neurology, University Hospitals Leuven, Leuven, Belgium.
Brain and behavior
|November 11, 2023
概括
亚临床型活动 (SEA) 和睡眠障碍在阿尔茨海默病 (AD) 中很常见. 在阿尔茨海默病患者中,SEA更为普遍,他们也经历了较差的睡眠质量和增加的睡眠呼吸障碍.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 神经退行性疾病 神经退行性疾病
背景情况:
- 亚临床形活动 (SEA) 和睡眠障碍在阿尔茨海默病 (AD) 中很常见.
- 无论是SEA还是睡眠问题,都与认知功能有关,可能对AD有治疗意义.
- 在AD中,SEA和睡眠障碍之间的关系需要进一步研究.
研究的目的:
- 研究阿尔茨海默氏病 (AD) 患者的亚临床型活动 (SEA) 和睡眠障碍之间的潜在关系.
主要方法:
- 一项涉及48名阿尔茨海默病患者 (未被诊断为) 和34名对照者的横截面研究.
- 利用24小时的门诊电脑图 (EEG) 和多睡眠图来评估SEA和睡眠参数.
- 在AD患者和对照人群中比较睡眠特征和SEA患病率.
主要成果:
- 在阿兹海默症患者中,SEA的流行率是阿兹海默症患者的3倍,主要是在N2睡眠期间的前部区域.
- 阿尔茨海默病患者的睡眠效率较低,入睡后觉醒增加,更多的觉醒,更高的N1%,REM睡眠减少,呼吸暂停-呼吸暂停指数 (AHI) 和氧气不和指数 (ODI) 升高.
- 与SEA (AD-Epi+) 的AD小组与对照组相比,显示REM睡眠减少和AHI/ODI增加.
结论:
- 减少REM睡眠和更严重的睡眠呼吸障碍可能与AD中的SEA有关.
- 这些发现表明,在阿尔茨海默氏症中,睡眠和型活动的交叉点上存在潜在的诊断和治疗含义.
- 需要进一步的研究来探索睡眠障碍和阿尔茨海默病中SEA之间的复杂关系.
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