纤维细胞生长因子23独立地预测了急性冠状动脉综合征后的不良结果
Andrea Kallmeyer1,2, Ana Pello1,2, Ester Cánovas1
1Department of Cardiology, IIS-Fundación Jiménez Díaz, Madrid, Spain.
ESC heart failure
|November 11, 2023
概括
矿物代谢成分,包括纤维细胞生长因子23 (FGF23) 和二醇,预测心力衰竭和急性冠状动脉综合征 (ACS) 后的死亡. 这些发现在各个患者群体中是一致的,不仅限于患有病的人.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 矿物代谢 (MM) 异常与心血管疾病有关.
- 急性冠状动脉综合征 (ACS) 后的MM的预后意义仍然未得到充分探索.
研究的目的:
- 研究矿物代谢标志物在ACS后患者的预后作用.
- 评估MM组件与心血管不良结果之间的关联.
主要方法:
- 纤维细胞生长因子23 (FGF23),卡尔西迪奥尔,帕拉荷尔蒙,克洛托和酸盐的血水平在1190名ACS患者的出院时被测量.
- 随访患者的综合结果包括缺血事件,心力衰竭 (HF) 和死亡.
- 多变量分析被用来确定结果的独立预测因素.
主要成果:
- 纤维细胞生长因子23 (FGF23),二醇,先前的心血管疾病和高血压独立预测了主要结果.
- FGF23和副荷尔蒙预测心力衰竭 (HF),而FGF23和卡尔西预测死亡.
- 没有生物标志物预测了急性缺血事件;FGF23预测了即使在功能保留 (eGFR>60mL/min/1.73m2) 的患者的结果.
结论:
- 纤维细胞生长因子23 (FGF23) 和其他矿物代谢成分是HF和ACS后死亡的独立预测因素.
- 这些MM标志物的预后影响在各种患者亚组中是一致的.
- 这些关联超出了慢性病患者的范围,突出了对心血管风险评估的更广泛影响.
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