关于癌症基因组测试的患者决定:一项探索性研究
Margaret M Emmet1, Yuchiao Chang2, Daniel C Chung1,3
1Center for Cancer Risk Assessment, Massachusetts General Hospital, Boston, Massachusetts, USA.
Journal of genetic counseling
|November 11, 2023
概括
大多数癌症患者选择大型基因组进行基因测试,但测试选择是复杂的,受种族和教育等因素的影响. 癌症遗传测试中的差异仍然存在.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 医学社会学 医学社会学
背景情况:
- 多基因小组测试越来越多地用于癌症遗传咨询.
- 关于特定小组选择的患者决策尚未完全理解.
- 了解患者的偏好对于优化遗传咨询服务至关重要.
研究的目的:
- 在癌症遗传咨询环境中调查影响患者选择多基因面板测试的因素.
- 为了确定患者人口统计学,关注点和遗传测试决策之间的关联.
- 为了探索患者对不同类型基因组的偏好.
主要方法:
- 在癌症遗传咨询诊所对228名患者及其遗传咨询师的调查.
- 评估人口统计和临床特征,患者关切和会议结果.
- 分析与选择特定多基因小组测试相关的因素.
主要成果:
- 85.1%的患者进行了基因检测,56.2%选择了大型胰腺癌小组.
- 白人患者比非白人的患者更有可能接受测试.
- 测试选择与所提供的选项数量,教育,年龄和NCCN指南状态有关,以及对查和家庭动态的担忧.
- 患者的收入,癌症诊断和家庭结构并不能预测测试的选择.
结论:
- 患者表现出对大型基因面板的强烈偏好,但测试选择复杂且难以预测.
- 结果突出了癌症遗传测试获取和采用现有的差异.
- 需要进一步的研究,以充分理解患者对多基因面板测试的决策过程.
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