快速的唾液分析GC-MS与冷EI和开放式探针快速GC-MS与冷EI用于检测大麻使用
Oneg Elkabets1, Benny Neumark1, Aviv Amirav1,2
1School of Chemistry, Tel Aviv University, Tel Aviv, Israel.
Journal of mass spectrometry : JMS
|November 11, 2023
概括
通过快速的唾液分析,检测司机使用大麻变得更加简单. 这种方法可以快速识别delta-9-tetrahydrocannabinol (delta-9-THC) 和cannabidiol (CBD),而无需样本准备,有助于执法.
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
- 大麻素分析分析
背景情况:
- 唾液为药物检测提供了一个不那么侵入性的,更容易获得的替代血液.
- 精确和快速检测唾液中的大麻化合物对于执法部门来识别驾驶员的安全至关重要.
- 现有的方法可能缺乏现场或立即路边分析所需的速度和简单性.
研究的目的:
- 开发和验证一种超快速的方法来检测唾液中的三角形9-四大麻素 (三角形9-THC) 和大麻素 (CBD).
- 用唾液样本对大麻消费进行快速,现场或现场附近的分析.
- 为执法部门提供一个工具,以便快速评估因大麻使用而导致的驾驶员损伤.
主要方法:
- 使用气相色谱-质谱法 (GC-MS) 与冷电子电离 (Cold EI) 进行敏感和选择性检测.
- 采用开放式探针快速GC-MS与冷EI分析周期时间小于一分钟.
- 开发了一种使用玻璃棒的直接唾液分析技术,在GC注射器中进行热溶解,从而消除了样品制备.
主要成果:
- 通过使用开放式探针快速GC-MS与冷EI实现了不到一分钟的全唾液分析周期时间.
- 证明了区分三角形9-THC和CBD同位素的能力.
- 证实唾液样本可以在没有任何先前准备的情况下直接分析,简化了工作流程.
结论:
- 开发的超快速开放式探针快速GC-MS与冷EI方法提供了一个高效的工具,用于大麻化合物的唾液分析.
- 这种技术可以很容易地从各种产品中检测到大麻的消费,帮助执法部门在路边或现场测试中进行检测.
- 该方法的速度,简单性和区分关键大麻素的能力使其成为法医毒理学的宝贵进步.
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