高血压持续时间对白质结构的影响及其与认知的联系
Zilin Li1,2, Feng Sang1,2, Zhanjun Zhang1,2
1State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
概括
较长的高血压持续时间会恶化执行功能和处理速度等认知功能,同时增加白质变化. 这些神经效应随着时间的推移而累积.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 认知科学 认知科学
背景情况:
- 高血压对认知的影响显示出混合的结果,可能受疾病持续时间的影响.
- 了解高血压持续时间对大脑健康的累积影响至关重要.
研究的目的:
- 研究高血压持续时间如何影响认知功能.
- 探索与高血压持续时间相关的潜在宏观结构 (WMH) 和微观结构白质 (WM) 变化.
主要方法:
- 1218名患者 (≥55岁) 接受了神经心理评估.
- 一个233名患者的小组有成像数据,按高血压持续时间分类:短 (<5年),中等 (5-20年) 和长 (>20年).
- 分析包括白质超强度 (WMH) 和白质完整性,使用先进的成像技术,如自由水成像.
主要成果:
- 延长高血压持续时间与较差的执行功能和处理速度相关.
- 观察到更严重的白质高强度 (WMH) 与更长的高血压持续时间,特别是在长时间的组.
- 白质完整性早早下降,特别是在远程区域,逐渐影响整个大脑.
- 增加WMH和减少WM完整性与执行功能受损有关.
结论:
- 高血压引起的神经损伤是累积的.
- 通过神经成像检测到的宏观和微观结构白质变化是高血压渐进性认知影响的关键指标.
- 自由水成像增强了与高血压相关的白质变化的检测.
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