在基于UPLC-Q-Orbitrap-MS技术的Jianwei Xiaoshi药片的化学成分分析
Jie Ma1, Shenshen Yang1, Huiru Liu1
1School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Natural product research
|November 11, 2023
概括
建伟小石药片 (JXT) 是一种治疗腹的传统中医药,其复杂的化学成分已被分析. 研究人员使用先进的质谱技术确定了93种化合物,包括黄类和类.
科学领域:
- 药理学 药理学是指药理学的学科.
- 分析化学 分析化学
- 传统中国医药 传统中国医药
背景情况:
- 建伟小石片 (JXT) 是一种用于消化不良的复合草药制剂.
- JXT的化学成分是复杂的,并未完全理解.
- 准确识别JXT的成分对于质量控制和了解其治疗效果至关重要.
研究的目的:
- 综合分析和识别伟小石片 (JXT) 的化学成分.
- 建立一个可靠的方法,快速分类和识别JXT的化学成分.
- 为促进这种传统中医药的质量控制和药理学理解做出贡献.
主要方法:
- 超高性能液体色谱-四极-轨道-质谱法 (UPLC-Q-轨道-MS) 用于样本分析.
- 通过使用JXT.的五种单个草药的质谱数据构建了一个化合物数据库.
- 来自JXT样品的质谱数据与已建立的组件识别数据库进行了比较.
主要成果:
- 在JXT.中,共有93个化学成分被成功识别出来.
- 已识别的成分包括6种氨基酸,34种黄,18种,15种有机酸和9种循环.
- 该研究证明了快速分类和识别JXT化学成分的可行性.
结论:
- UPLC-Q-Orbitrap-MS方法为JXT的化学分析提供了一种有效的方法.
- 这项研究阐明了JXT复杂的化学成分,有助于其标准化.
- 这些发现支持质量控制和进一步研究伟小石片的疗效.
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