乙烯氧化物暴露与"生命必需8"的关联
Ruijie Xie1,2,3, Linjian Liu4, Changxiong Liu1
1Department of Hand & Microsurgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, 421002, China.
Environmental science and pollution research international
|November 11, 2023
概括
乙烯氧化物 (EtO) 暴露与较差的心血管健康 (CVH) 有关,根据生命的基本8分数来衡量. 较高的EtO水平与心血管血压降低和心血管死亡风险增加相关.
科学领域:
- 环境健康 环境健康
- 心血管科学 心血管科学
- 毒理学 毒理学 毒理学
背景情况:
- 乙烯氧化物 (EtO) 是一种常见的工业化学品,具有已知的健康风险,包括致癌性.
- 新兴研究表明,EtO暴露与心血管疾病之间存在潜在联系.
- 生活必需品8 (LE8) 评分提供了心血管健康 (CVH) 的综合测量.
研究的目的:
- 通过使用LE8评分来调查ETO暴露和CVH之间的关联.
- 探索EtO暴露与心血管死亡率之间的关系.
主要方法:
- 分析了国家健康和营养检查调查 (NHANES) 中3748名成年人的数据.
- 使用LE8得分 (饮食,体力活动,烟草,睡眠,BMI,胆固醇,葡萄糖,血压) 评估CVH.
- 通过使用线性和考克斯回归模型检查通过血红蛋白添加物 (HbEtO) 水平对EtO暴露的检查.
主要成果:
- 在EtO暴露和整体CVH得分之间发现了反向关系.
- 在In转化HbEtO中增加1个单位与CVH得分下降3.69个点有关.
- 较高的EtO暴露与心血管死亡率的增加有关,但与全因死亡率无关.
结论:
- 升高的EtO暴露与LE8.8定义的心血管健康指标有负面关联.
- 这些发现表明,与ETO暴露相关的显著心血管风险,特别是超过一定的值.
- 需要进一步的研究,以了解与EtO相关的心血管风险的机制,并制定预防策略.
相关概念视频
01:36Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
01:26Toxic Reactions: Overview
991
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
991
01:29Oxygen Requirements and Growth Patterns
26
Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the terminal...
26
01:20Radical Autoxidation
2.2K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
2.2K
01:38Nucleotide Excision Repair
3.5K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
3.5K
02:41Lethal Alleles
15.5K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
15.5K