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大脑多巴胺受体系统在肥胖中没有改变:贝叶斯式和频率主义的元分析
Kyoungjune Pak1,2, Lauri Nummenmaa3,4,5
1Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Human brain mapping
|November 11, 2023
概括
大脑多巴胺受体 (DR) 的可用性在瘦身和超重/肥胖个体之间没有显著差异. 然而,根据使用的特定放射性药物和肥胖程度,研究结果会有所不同.
科学领域:
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
- 放射化学 放射化学是指辐射化学.
背景情况:
- 条形体中多巴胺信号传递对于奖励处理至关重要.
- 多巴胺奖励系统的失调与过度饮食和肥胖有关.
- 以前使用正子发射断层扫描 (PET) 对肥胖症中多巴胺受体 (DR) 可用性的研究已经产生了不一致的结果.
研究的目的:
- 为了研究条状多巴胺受体可用性和超重/肥胖之间的关联.
- 通过元分析来协调文献中不一致的发现.
主要方法:
- 在Embase,Medline,Scopus和Web of Science的系统文献搜索相关研究.
- 包含了九项研究,比较了瘦身者与超重/肥胖者之间的条形性DR可用性.
- 利用贝叶斯式和频率主义元分析方法,计算DR可用性的标准化平均差异 (Hedge's g).
- 基于身体质量指数 (BMI) 的分层分析 (25和30 kg/m2) 的截止值.
主要成果:
- 贝叶斯式和频率主义的元分析都显示,瘦身和超重/肥胖者之间的DR可用性没有显著差异,结果重叠为零.
- 放射性药物的选择影响了在使用BMI截止值为25 kg/m2时DR可用性的标准化平均差异.
- 在不同放射性药物和BMI定义中,DR可用性和超重/肥胖之间没有发现一致的关联.
结论:
- 大脑多巴胺受体的可用性似乎在瘦身和超重/肥胖个体之间没有差异.
- 观察到的效应取决于所使用的特定放射性药物和肥胖程度.
- 建议在同一个人身上使用多种放射性药物成像进行进一步的研究,以澄清DR-肥胖关系.
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