通过thalamic commissures进行直接的半球间皮层通信:灵长类大脑中的新白质通路
Diego Szczupak1, David J Schaeffer1, Xiaoguang Tian1
1University of Pittsburgh Brain Institute, Department of Neurobiology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA.
Cerebral cortex (New York, N.Y. : 1991)
|November 11, 2023
概括
thalamic commissures (TCs) 将皮质与灵长类动物的逆侧 thalamus 连接起来,类似于动物. 这些通路存在于灵长类动物中,特别是在人类大脑形的情况下.
科学领域:
- 神经科学是一个神经科学.
- 比较解剖学的比较解剖学
- 神经成像是一种神经成像.
背景情况:
- 类哺乳动物通常使用像体这样的主要指挥官来进行半球间皮层连接.
- thalamic commissures (TCs) 最近被确定为动物中的一个额外的途径,将皮质连接到逆侧 thalamus.
- 灵长类动物中TCs的存在和作用在很大程度上仍然没有被描述.
研究的目的:
- 为了研究灵长类大脑中乳头部通道 (TC) 的存在和连接性.
- 为了比较不同灵长类动物和动物的TC发育和功能.
- 探索TCs在人类大脑形中的潜在作用.
主要方法:
- 高分辨率的扩散权重磁共振成像 (dMRI).
- 病毒轴突追踪技术.病毒轴突追踪技术.
- 功能性磁共振成像 (fMRI). 功能性磁共振成像.
- 在新世界,旧世界灵长类动物和人类受试者之间进行比较分析.
主要成果:
- 在新世界 (马尔莫塞特,) 和旧世界 () 灵长类动物中发现了thalamic commissures (TCs).
- 像动物一样,灵长类动物中的TCs在胚胎发育并形成活跃的解剖和功能连接.
- 在患有脑形的人群中观察到TC,但在健康人群中没有.
结论:
- 塔拉姆体管 (TCs) 是灵长类大脑中重要的半球间通路,增强了连接性和同步性.
- 电脑结晶可以作为一种替代的结晶路线,特别适用于发育性脑形.
- 这项研究强调TCs是哺乳动物大脑进化和发育中的重要,保存的途径.
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