腹中介前额叶皮层的电刺激调节肌肉交感神经活动和血压
Joe A Braun1,2, Mariya Patel1,3, Luke A Henderson4
1Baker Heart and Diabetes Institute, 75 Commerical Road, Melbourne, VIC 3004, Australia.
Cerebral cortex (New York, N.Y. : 1991)
|November 11, 2023
概括
腹中中枢前额叶皮层的跨交替电流刺激会影响肌肉交感神经活动和血压. 与右侧相比,左中腹前额皮层刺激导致血压大幅下降.
科学领域:
- 神经科学是一个神经科学.
- 自主神经科学 自主神经科学
- 人体生理学 人体生理学
背景情况:
- 以前的研究表明,背侧前额叶皮层的跨交替电流刺激 (tACS) 影响肌肉交感神经活动 (MSNA),心率和血压.
- 目前的研究研究了tACS对腹中前额叶皮层 (vmPFC) 的影响,假设MSNA的调制类似,尽管可能更弱.
研究的目的:
- 测试左和右vmPFC的tACS是否对人类的MSNA进行调节.
- 为了比较左与右vmPFC刺激对MSNA的调节效应.
- 为了比较vmPFC刺激效应与背侧前额皮层 (dlPFC) 刺激效应.
主要方法:
- 11名参与者接受了MSNA的微电极记录,来自右侧常神经.
- 持续监测血压,心电图和呼吸.
- 在nasion和FP1 (左边vmPFC) 或FP2 (右边vmPFC) 电极之间以0.08Hz,±2mA的频率应用tACS.
- 为了进行比较,tACS也应用于F4 (右 dlPFC).
主要成果:
- 刺激所有三个皮质部位 (左vmPFC,右vmPFC,右dlPFC) 部分带动MSNA到刺激频率.
- 所有刺激部位都调节了血压和心率.
- 与右侧vmPFC刺激相比,在左侧vmPFC刺激期间观察到平均血压 (~6 mmHg) 的显著下降 (P=0.039).
结论:
- 这项研究提供了第一个证据,即vmPFC的tACS调节休息时清醒的人类的MSNA和血压.
- 左侧vmPFC刺激比右侧vmPFC刺激更大降低了血压.
- 调解vmPFC刺激对自主控制的影响的精确神经通路仍有待阐明.
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