孕激素激活了基斯乳酸-Hif1α-糖解反循环,以促进决定化
Wei Zhao1, Yue Wang1, Juan Liu1
1State Key Laboratory of Animal Biotech Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 1000193, P.R. China.
Endocrinology
|November 11, 2023
概括
子宫中的乳酸生产对于怀孕至关重要. 这项研究揭示了乳酸如何通过激素乳化和涉及Hif1α的反循环驱动决定化,为改善妊娠结果提供了新的见解.
科学领域:
- 生殖生物学 生殖生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 代谢调节 代谢调节 代谢调节
背景情况:
- 脱二化,一种由孕激素驱动的过程,对于怀孕的确立至关重要.
- 在决定化过程中增强糖解和乳酸生产的作用尚不清楚.
- 基因组乳基化 (H4K12la) 是一种新发现的表观遗传修饰.
研究的目的:
- 为了研究子宫内膜乳酸生产在决定化中的功能.
- 为了阐明基因素乳酸化在子宫重塑中的作用.
- 确定将新陈代谢,表观遗传学和决定化联系在一起的分子机制.
主要方法:
- 在体内和体内决定化模型.
- 基斯修饰分析 (CUT&Tag).
- 染色体可访问性测定 (ATAC-seq).
- 对基因表达和蛋白质相互作用的分析.
主要成果:
- 子宫内膜的乳酸生产对于建立基因素乳化 (H4K12la) 是必不可少的.
- H4K12la直接调节了转录因子低氧诱导因子1α (Hif1α) 的转录因子.
- 由孕激素激活的H4K12la-Hif1α-糖解反循环驱动了决定化.
- 抑制组织素乳化会影响决定性化.
结论:
- 乳酸驱动的基因素乳酸化是子宫内膜分泌的关键调节剂.
- 在孕激素,子宫内膜代谢和表观遗传修饰之间建立了新的联系.
- 这些发现为改善生育能力和妊娠结果提供了潜在的目标.
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