垂体腺体体积和压力:基于人口成年人样本的结果
Johanna Klinger-König1, Till Ittermann2, Insa I Martin2
1Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Journal of psychiatric research
|November 11, 2023
概括
较大的垂体体积与抑郁症状的增加相关,特别是在童年被忽视后. 这种关联与抑郁症患者的皮质醇水平变化有关,这表明早期压力和垂体功能之间存在联系.
科学领域:
- 神经内分泌学神经内分泌学
- 精神病学是一个精神病学.
- 人类生物学 人类生物学
背景情况:
- 早期和慢性压力可以破坏下丘脑-垂体-上腺 (HPA) 轴,影响皮质醇分泌.
- 关于压力标志物和垂体体积的先前研究是有限的,通常专注于特定人群.
- 童年逆境,垂体大小和与压力相关的结果之间的相互作用需要在一般人群中进一步调查.
研究的目的:
- 为了研究垂体体积与抑郁症状之间的关联.
- 检查童年虐待和忽视对垂体体积和抑郁症状的相互作用影响.
- 为了探索垂体体积,抑郁症状和血清皮质醇度之间的关系.
主要方法:
- 利用了来自两个成人一般人口队伍 (SHIP-START-2和SHIP-TREND-0) 的数据.
- 采用线性回归模型来评估主要和相互作用效应.
- 综合了两个队列的发现,使用元分析,结果包括抑郁症状 (贝克抑郁 inventory-II) 和血清皮质醇.
主要成果:
- 在垂体体体积和抑郁症状之间没有发现显著的主要影响.
- 较大的垂体体积与报告更严重的童年疏忽的个体的抑郁症状增加有关 (元分析:β = 0.066,p = 0.015).
- 在患有更严重抑郁症状的人群中,较大的垂体体积与较低的血清皮质醇度相关 (元分析:β = -0.063,p = 8.39e-05).
结论:
- 较大的垂体体积与更严重的精神病理症状有关,特别是在有早期生活压力史的人群中.
- 这些发现表明,垂体体积在调解早期压力对心理健康的影响方面可能发挥作用.
- 在具有显著荷尔蒙变化的发育阶段和临床患者样本中,需要进一步研究.
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