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在瘤免疫治疗中,外体的生物学和功能

Can Liu¹, Cong Xia², Chenglai Xia¹

¹Foshan Maternity and Chlid Healthcare Hospital, Foshan 528000, China; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 515150, China.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

|November 11, 2023

概括

外体,微小的带有生物信息的囊泡,显示出希望作为无细胞疫苗和癌症免疫治疗的药物输送系统. 标准化和临床试验的挑战仍然存在,但外体细胞提供了瘤治疗的新时代.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物技术是生物技术.

背景情况:

外体是纳米尺度的细胞外囊泡,参与细胞间通信.
目前的癌症免疫疗法在有效性和副作用方面面临限制.

研究的目的:

审查瘤免疫治疗中外体的潜力和挑战.
突出外体作为癌症治疗的新工具.

主要方法:

在癌症免疫治疗中对外体组应用的文献综述.
对疫苗和药物输送潜力的外体属性的分析.
讨论当前的挑战和未来的方向.

主要成果:

外体细胞可以通过呈现抗原和免疫刺激分子来充当无细胞疫苗.
外体因其稳定性,低免疫性和准能力而作为有效的药物递送系统.
工程外体可以精确地准瘤细胞以增强治疗效果.

结论:

外基因组对推进瘤免疫治疗具有重大前景.
隔离/净化标准化和改善货物装载是至关重要的.
进一步的大规模临床试验是必要的,以验证基于外体的疗法.

关键词:

药物输送系统是药物输送系统.外基因组是外基因组的组成部分.瘤免疫疗法免疫疗法这是瘤疫苗.

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