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在被诊断为急性中风后失语症的患者中,语言和非语言大脑网络的功能连接性发生变化

Liying Han¹, Jun Ke², Dawei Zhang¹

¹Department of Physical Medicine & Rehabilitation, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.

Clinical neurology and neurosurgery

|November 11, 2023

概括

休息状态的fMRI揭示了急性中风后失语症 (PSA) 患者的功能连接 (FC) 受到干扰,脑网络通信发生变化与失语症严重程度相关. 这些发现凸显了FC的重要地位.

科学领域:

神经科学是一个神经科学.
放射学放射学是一门学科.
神经学神经学

背景情况:

急性中风后失言症 (PSA) 带来了重大的沟通挑战.
了解PSA的神经支对于有效治疗至关重要.
休息状态功能磁共振成像 (rs-fMRI) 提供了对大脑网络功能的洞察.

研究的目的:

在急性PSA患者的语言和非语言大脑网络中研究功能连接 (FC),使用rs-fMRI.
探索PSA中FC变化和临床表现 (失言症严重程度) 之间的关系.
为了确定特定的大脑区域和参与PSA病变的网络.

主要方法:

招募了20名急性PSA患者和30名健康对照 (HC) 用于rs-fMRI.
使用西方失语电池 (WAB) 计算PSA患者的失语率 (AQ).
采用格兰杰因果关系和REST加软件用于对选定的ROI进行FC分析,包括Broca和Wernicke的面积同类.

主要成果:

在PSA患者中,右中额头 (RMFG) 和左中尾 (LMOG) 之间的FC增加,与AQ正相关.
在布罗卡的区域同类和左中额头 (LMFG) 之间观察到减少的FC.
在Wernicke的区域同类和小脑虫之间发现了增强的FC,同样与AQ正相关.

结论:

急性PSA的特点是中断的半球间FC,影响语言网络.
在PSA患者中,失言症的严重程度与多个大脑区域的改变FC相关.
FC模式为理解和潜在治疗PSA提供了潜在的生物标志物.

关键词:

严重的中风后急性中风.亚法西亚 (Aphasia) 是一种语言障碍.功能连接性的功能连接性.语言网络语言网络

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