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MTOR基因变异与严重的COVID-19结果有关:一个多中心研究

Bruna Ramos Tosta¹, Ingrid Marins de Almeida¹, Laiane da Cruz Pena¹

¹Laboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Brazil.

International immunopharmacology

|November 11, 2023

概括

哺乳动物目标拉巴素 (mTOR) 途径中的遗传变异与严重的COVID-19结局有关. 特定的MTOR变种增加了严重疾病和死亡的风险,这表明它在COVID-19病变发生过程中发挥了作用.

科学领域:

免疫学免疫学免疫学
遗传学遗传学是一个
传染性疾病传染性疾病

背景情况:

严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染可以引发细胞因子风暴,这是严重的冠状病毒疾病2019 (COVID-19) 发病的一个关键因素.
哺乳动物目标的拉巴胺素 (mTOR) 途径调节先天性免疫反应,包括细胞因子的产生,并且在严重的COVID-19中经常失调.
个体遗传变异可能会影响对SARS-CoV-2免疫反应的严重程度.

研究的目的:

研究MTOR基因中的特定遗传变异与COVID-19结果之间的关联.
为了确定MTOR变种是否有助于COVID-19感染的严重程度.

主要方法:

在患有严重 (n=285) 和轻度 (n=207) COVID-19 的个体中,对MTOR变异 (rs1057079和rs2536) 的基因定型.
使用后勤回归分析和卡普兰-梅尔生存曲线来评估变异和结果之间的关联.
测量瘤亡因子 (TNF) 和IL-6 (IL-6) 的血水平,并应用基因型风险评分.

主要成果:

MTOR rs1057079的T等位基因与严重COVID-19的可能性增加有关.
MTOR rs2536的T等位基因与更高的IL-6水平和增加的COVID-19死亡率有关.
当这些MTOR变异被共同遗传时,观察到累积风险.

结论:

MTOR基因变异可能在严重的COVID-19中发挥病原遗传作用.
这些发现可以帮助预测COVID-19感染的严重后果.
识别有风险的个体可能会允许更有效地分配医疗保健资源.

关键词:

在 COVID-19 疫情中,遗传变体的遗传变体非常严重的严重.在mTOROR中使用mTOR.

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