建议针对早期发生的子宫内膜异位症和腺髓异位症进行有针对性的,以新进化为导向的二次预防. 第一部分:病原性方面
Paolo Vercellini1,2, Veronica Bandini1, Paola Viganò1,2
1Department of Clinical Sciences and Community Health, Academic Centre for Research on Adenomyosis and Endometriosis, Università degli Studi, Milano, Italy.
Human reproduction (Oxford, England)
|November 11, 2023
概括
反复排卵和月经,曾经有利,现在增加疾病的风险,由于现代的生活方式. 这种进化不匹配可能解释了青少年子宫内膜异位症和腺菌症的发病率上升.
科学领域:
- 进化生物学是进化的生物学.
- 生殖健康 生殖健康
- 妇科 妇科医生 妇科
背景情况:
- 从历史上看,由于初潮迟到,早产和长时间母乳养,女性的排卵周期很少.
- 现代生活方式的特点是更早的初潮,更晚的分娩和更短的母乳养时间.
- 这种转变造成了基因适应和社会环境条件之间的不匹配.
研究的目的:
- 探索生殖变化对妇科健康的进化影响.
- 调查增加的排卵周期与子宫内膜异位症和腺菌症等疾病之间的联系.
- 质疑无排卵和异常是否应该被认为是经月经后个体的生理状态.
主要方法:
- 文学评论和历史生殖模式的分析.
- 检查与社会环境变化有关的疾病发病率趋势.
- 在子宫内膜异位症和腺菌症的病原性因素的假设性探索.
主要成果:
- 向频繁排卵周期的转变可能会增加对雌激素相关癌症的易感性.
- 假设反复排卵会导致子宫内膜异位症和腺菌症.
- 子宫内膜异位症的发病率可能被低估,其潜在根源在青春期.
结论:
- 祖先和现代生殖模式之间的不匹配给健康带来了风险.
- 需要进一步的研究来证实排卵周期与子宫内膜异位症/腺菌症之间的联系.
- 激素干预可以考虑在处于风险的青少年中进行二次预防.
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