免疫疗法和向疗法作为先进胃癌的第一线治疗
Guocheng Wang1, Yan Huang2, Liang Zhou1
1Department of Gastrointestinal Surgery, The 966 Hospital of the Joint Logistic Support Force of the People's Liberation Army, Dandong, China.
Critical reviews in oncology/hematology
|November 11, 2023
概括
对于晚期胃癌,以FGFR2b为向的治疗 (bemarituzumab_chemo) 显示了最高的疗效. 免疫疗法组合 (Sintilimab_chemo) 和CLAUDIN 18.2向疗法 (zolbetuximab_chemo) 也有好处,在HER2阳性病例中使用trastuzumab_chemo.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 晚期胃/胃食道癌的标准一线治疗包括胺和化疗.
- 新型药物,包括基于免疫和向治疗,正在探索以改善患者的治疗结果.
研究的目的:
- 进行网络元分析,比较高级胃或胃食道癌症的第一线组合治疗方法.
- 评估与标准化疗相比,新型治疗组合的疗效和安全性.
主要方法:
- 22个随机对照试验的网络元分析.
- 包括17个不同的治疗方案中的10,787名患者.
- 评估总生存率 (OS),无进展生存率 (PFS),客观反应率 (ORR) 和3-4级治疗相关不良事件 (TRAE).
主要成果:
- 针对FGFR2b的治疗 (bemarituzumab_chemo) 显示出最高的疗效.
- 基于免疫治疗的疗法 (CPS ≥5,Sintilimab_chemo) 显示出显著的益处.
- 对于HER2阳性患者,克劳丁18.2向治疗 (zolbetuximab_chemo) 和trastuzumab_chemo也具有优势.
结论:
- 以FGFR2b为向的疗法代表了对晚期胃/胃食道癌症的有前途的第一线选择.
- 涉及免疫疗法和向药物的组合疗法提供了更好的结果.
- 个性化治疗选择,包括HER2阳性患者的trastuzumab_chemo,对于优化患者护理至关重要.
更多相关视频
10:28Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
11.1K
07:55Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
Published on: January 17, 2025
778
相关概念视频
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
01:27Tumor Immunotherapy
533
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
533
01:30Cancer Vaccines
380
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
380
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:26Peptic Ulcer Disease IV: Management
96
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
96