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对于前列腺癌的激进前列腺切除术后的国家长期生存估计
Kristian D Stensland1, Megan E V Caram2, Daniel J Herr3
1Department of Urology, University of Michigan, Ann Arbor, MI.
Urology
|November 11, 2023
概括
与历史数据相比,在急性前列腺切除术后复发前列腺癌的男性的生存率有所改善. 这些更新的前列腺癌复发和转移的生存估计对于患者咨询和临床试验设计至关重要.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 医学统计 医学统计
背景情况:
- 激进前列腺切除术是局部前列腺癌的主要治疗方法.
- 了解手术后的长期结果,包括复发和转移,对于患者管理至关重要.
- 需要对前列腺癌患者的当代生存数据来反映当前治疗疗效.
研究的目的:
- 为了评估生存和疾病控制,包括转移相关的结果,在一个大队伍的患者治疗局部前列腺癌的急性前列腺切除术.
- 为在前列腺癌手术后经历生化复发或转移的男性提供最新的生存估计.
- 以当前的结果数据为基础,为患者咨询和临床试验设计提供信息.
主要方法:
- 在退伍军人卫生管理局内对21,992名患有局部前列腺癌的男性进行了彻底前列腺切除 (2005-2015) 的回顾性分析.
- 生物化学复发 (BCR) 定义为前列腺特异性抗原 (PSA) ≥0.2 ng/mL;转移性前列腺癌使用验证的自然语言处理数据集确定.
- 卡普兰-梅尔和累积发病率方法用于估计整体存活率,无BCR存活率,无转移存活率和前列腺癌特定存活率.
主要成果:
- 27%的患者 (5951/21,992) 发展了BCR;11%的BCR患者 (677/5951) 发展了转移.
- 据估计,BCR的10年累积发病率为28%,BCR后转移为20%.
- 经过BCR的平均整体存活时间为14年 (10年存活率为70%);经过转移的平均整体存活时间为7年 (10年存活率为34%). 在整个队列中,10年前列腺癌特异性存活率为94%.
结论:
- 在急性前列腺切除术后,生化复发前列腺癌的男性在与历史数据相比,在当代队伍中表现出更长的生存期.
- 对复发性和转移性前列腺癌的最新生存估计对于准确的患者咨询至关重要.
- 这些发现为设计未来的临床研究和前列腺切除术后患者的管理提供了有价值的基准.
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