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京颗粒通过调节粘脂蛋白1的表达减轻了Coxsackievirus B3引起的心肌损伤

Bowen Sun¹, Lin Lin¹, Tian Yao¹

¹Innovation Research Institute of traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.

Journal of ethnopharmacology

|November 11, 2023

概括

京颗粒 (JFG) 通过增强自和线粒体功能的作用,可以预防Coxsackievirus B3诱导的病毒性心肌炎 (VMC). 这种传统草药可减少心脏损伤并抑制细胞亡,为VMC提供潜在的治疗策略.

科学领域:

心血管研究研究心血管研究
免疫学免疫学免疫学
传统中国医药传统中国医药

背景情况:

京方颗粒 (JFG) 是源自用于病毒性疾病的传统草药配方.
治疗病毒性心肌炎 (VMC) 的JFG机制需要进一步调查.
考克萨基病毒B3 (CVB3) 是病毒性心肌炎的常见原因.

研究的目的:

评估JFG对CVB3诱导的VMC的治疗疗效.
阐明JFG在VMC治疗中的潜在分子机制.

主要方法:

建立了CVB3诱导的VMC的小鼠模型,并用JFG或oseltamivir进行治疗.
分析了心脏病理,炎症标志物和基因表达.
转录组分析确定了Mcoln1作为一个关键基因;其作用在H9C2细胞中使用siRNA敲除和各种细胞测试 (qRT-PCR,JC-1染色,ROS检测) 进行了研究.

主要成果:

在VMC小鼠中,JFG治疗显著降低了心脏病理损伤和炎症基因表达.
转录组分析揭示了Mcoln1上调,这促进了自和清除受损的线粒体和活性氧物种 (ROS).
实验室研究证实,Mcoln1在H9C2细胞中的敲除损害了JFG增强自,改善线粒体功能,清除ROS和抑制亡的能力.

结论:

JFG证明了对CVB3诱导的H9C2细胞损伤的保护作用.
JFG很可能通过增强通过线粒体通路的自,抑制细胞亡和减轻细胞损伤来对VMC产生治疗作用.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.自自是一种自的过程.京 ?? 颗粒京 ?? 颗粒麦科伦是什么意思麦科伦是什么意思线粒体中的线粒体.病毒性心肌炎病毒性心肌炎

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