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双A (BPA) 和B (BPB) 对Xenopus laevis发育的致病性和神经行为毒性影响

F Metruccio¹, M Battistoni², F Di Renzo²

¹ICPS, ASST Fatebenefratelli Sacco, via GB Grassi, 74, 20159 Milan, Italy.

Reproductive toxicology (Elmsford, N.Y.)

|November 11, 2023

概括

双乙烯 (BPB) 是比双乙烯 (BPA) 更强大的内分泌干扰剂,在较低度下会导致Xenopus laevis的致命性和形. 这两种化学物质在较高剂量时都会诱导神经行为缺陷.

科学领域:

环境毒理学环境毒理学
发展生物学发展生物学
内分泌学在内分泌学.

背景情况:

双A (BPA) 是一种内分泌干扰物,已知对发育有不良影响.
双乙烯 (BPB) 是BPA的替代品,但其毒理学特征不太清楚.
两动物模型Xenopus laevis对内分泌干扰物敏感,对发育毒性研究有用.

研究的目的:

为了比较Xenopus laevis.中的Bisphenol B (BPB) 和Bisphenol A (BPA) 的发育毒性和内分泌干扰潜力.
评估BPB和BPA对致死率,发育不良和神经行为发展的影响.
为了确定与BPA相比,BPB的相对强度.

主要方法:

在特定的发育窗口 (原性和神经行为) 中,Xenopus laevis胚胎暴露于不同度的BPA和BPB.
标准化的R-FETAX方法用于暴露和评估外部形态,脱和致命性.
通过游泳测试评估神经行为毒性,通过软骨染色分析形.

主要成果:

死亡率和形仅在致性窗口中观察到,BPB的相对强度大约是BPA的3倍.
致命性与状原生的异常部发育和亡有关.
在神经行为窗口期间暴露于高度的BPA和BPB的头中检测到神经行为缺陷,但没有观察到产性.

结论:

在Xenopus laevis模型中,双乙比双甲具有更大的原性.
无论是BPA还是BPB都可能诱导神经行为缺陷,这表明共享的内分泌干扰机制.
这些发现突显了BPB作为BPA替代品的潜在风险,并强调需要仔细评估内分泌干扰化学品的风险.

关键词:

双醇是一种双醇.发展发展发展发展发展胚胎毒性胚胎毒性内分泌干扰物干扰内分泌干扰物怀孕怀孕怀孕怀孕

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