通过低温溶剂交换方法在生物相关溶剂中溶解桑,以开发生物相容的桑材料
Boxuan Li1, Li Qiu2, Jialuo Zhang2
1Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China.
International journal of biological macromolecules
|November 11, 2023
概括
一种新的低温方法成功地使酸盐在水等生物溶剂中溶解,克服了生物医学用途的溶解性问题. 这一过程产生了稳定,正电荷的酸盐伪溶液,这对于材料制造至关重要.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 生物技术是生物技术.
背景情况:
- 酸盐是生物医学应用的有前途的生物聚合物,因为它具有生物相容性和生物降解性.
- 酸盐在常见溶剂中的溶解性较差,严重限制了其加工和应用.
- 开发在生物兼容溶剂中溶解子的方法对于其更广泛的使用至关重要.
研究的目的:
- 开发一种在生物相关溶剂 (生物溶剂) 中溶解奇托的方法.
- 为了研究温度对酸盐溶解过程的影响.
- 描述产生的奇托伪溶液的特性和潜在应用.
主要方法:
- 奇托被溶解在一个离子液体 (IL),1-乙基-3-甲基利米达酸 (EMIM Ac) 中.
- 素/IL溶液在低温 (4°C) 上对生物溶剂 (水,盐水,细胞培养基) 进行透析.
- 分析了由此产生的奇托伪溶液的特性,包括泽塔潜力,体稳定性和风质学.
主要成果:
- 一种低温溶剂交换方法成功地产生了稳定的水性奇托伪溶液.
- 低温 (4°C) 对溶解至关重要;较高的温度 (50°C) 会导致水凝的形成.
- 基于水的伪溶液表现出高正泽塔电位 (+52.6 mV),良好的体稳定性和弱的液体凝类风湿学.
- 从这些伪溶液中轻松制造出各种基托基材料.
- 伪溶液和衍生产品都显示出高生物相容性.
结论:
- 使用离子液体的低温溶剂交换是一种有效的策略,可以在生物溶剂中溶解基托.
- 这种方法克服了基托的溶解性限制,使得能够创建先进的基托生物材料.
- 由此产生的生物相容的酸盐伪溶液为各种生物医学应用提供了显著的潜力.
相关概念视频
00:56Extraction: Advanced Methods
456
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
456
01:10Recrystallization: Solid–Solution Equilibria
1.1K
Recrystallization is a purification technique used to separate impurities from solid compounds. In this technique, no chemical reactions occur. Instead, it exploits physical properties only, specifically, the solubility differences between the desired compound and impurities, either at a single temperature or at different temperatures, and under other selected conditions. The solid-solution equilibrium (solubility equilibrium) of each component in the solution represents a binary phase...
1.1K
01:17Ion Exchange
596
Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or...
596