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性别差异在人类循环素相关心力衰竭的发展
Andrea Nathalie Rosas Diaz1, Gabriel Pajares Hurtado2, Abul Andres Ariza Manzano2
1Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
Journal of cardiac failure
|November 11, 2023
概括
在接受 antracyclines 的成年患者中,女性性别不会增加心力衰竭 (HF) 的风险. 这项研究发现,使用这些化疗药物治疗的成年人中,女性性别和发生的HF之间没有关联.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 儿科数据表明,女性性别是antracycline心脏毒性的危险因素.
- 性别在成年人中心脏毒性的作用尚不清楚.
- 这项研究解决了理解成年人心脏毒性基于性别差异的差距.
研究的目的:
- 为了评估女性性别对心力衰竭 (HF) 发病率的影响,在接受 antracycline 治疗的成年患者中.
- 为了澄清女性性别与成年人中抗环素诱导的心脏毒性之间的关联.
主要方法:
- 对1525名成年患者进行了回顾性队列研究,这些患者接受了环素治疗 (1992-2019).
- 排除标准包括先前的HF或心肌病.
- 主要结局:在5年内出现新的HF.
- 使用Cox比例危险和竞争风险模型进行统计分析.
主要成果:
- 在1.02年的中位数随访期间,4.78%的患者患上了HF (44名男性,29名女性).
- 在多变量模型中,女性性别与发生的HF没有显著的关联 (HR 0.87;P=0.58).
- 年龄,冠状动脉疾病和造血干细胞移植与HF有关.
结论:
- 女性性别与在成人患者中发生性心力衰竭的风险增加无关.
- 这些发现与一些儿科数据形成鲜明对比,强调需要针对成人进行有关心脏毒性风险因素的研究.
- 进一步的研究可能会探索在这个人群中导致心脏毒性的其他因素.
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