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埃诺沙巴林通过减少中性粒细胞外细胞陷 (NETs) 生产来改善COVID-19

Emily S Córneo¹, Flavio Protasio Veras², Giovanni F Gomes³

¹Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, Santa Catarina, Brazil.

Clinical immunology (Orlando, Fla.)

|November 11, 2023

概括

发现抗凝剂埃诺沙巴林可以降低中性粒细胞外细胞陷 (NETs) 和COVID-19患者和动物模型的炎症. 这表明,埃诺沙巴林在治疗COVID-19方面提供了超出其血液稀释功能的好处.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
药理学药理学是指药理学的学科.

背景情况:

COVID-19 感染导致免疫系统失衡和血栓事件.
感染期间过多的中性粒细胞外细胞陷 (NETs) 会促进炎症和扩散的血管内凝血.
研究埃诺沙巴林抑制NETs的潜力对于了解其在COVID-19中的治疗作用至关重要.

研究的目的:

评估埃诺沙巴林作为COVID-19中中性粒细胞外陷 (NETs) 的潜在抑制剂的作用.
在SARS-CoV-2感染模型中评估埃诺沙巴林对疾病症状,肺损伤和炎症标志物的影响.
为了确定enoxaparin是否会影响COVID-19患者的器官功能障碍.

主要方法:

使用了感染SARS-CoV-2的K18-hACE2动物模型.
包括23名住院COVID-19患者的队列,这些患者接受了埃诺沙巴林治疗或没有治疗.
雇佣了没有疾病的对照组进行比较.

主要成果:

在感染SARS-CoV-2的动物中,以诺沙巴林治疗降低了NETs水平,疾病严重程度和肺损伤.
观察到部分预防SARS-CoV-2进入和NETs合成由enoxaparin.
临床数据显示,素减少了炎症标志物,中性粒细胞中的NET和器官功能障碍.

结论:

埃诺沙巴林在COVID-19中表现出超出其抗凝活动的有益作用.
这项研究提供了证据,支持埃诺沙巴林在减轻COVID-19中NETs相关病理方面的作用.
埃诺沙巴林成为治疗COVID-19并发症的潜在治疗剂.

关键词:

埃诺克萨帕林是一种素.炎症标志物是一种炎症标志物.肺部损伤肺部损伤肺部损伤网络网络网络网络这就是SARS-CoV-2病毒.

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