在大动脉动脉瘤形成过程中,介质蛋白-1通路中的内皮细胞转移到介质细胞
Jessica K Millar1, Morgan Salmon2, Elias Nasser3
1Department of Surgery, University of Michigan, Ann Arbor, Mich; Department of Cardiac Surgery, University of Michigan, Ann Arbor, Mich.
The Journal of thoracic and cardiovascular surgery
|November 11, 2023
概括
内皮转移到介质细胞转移有助于大动脉动脉瘤疾病. 抑制互白素-1信号传递有效地减少了动脉瘤的发展和进展.
科学领域:
- 心血管生物学 心血管生物学
- 细胞生物学 细胞生物学
- 病理学 病理学 病理学
背景情况:
- 内皮细胞转移到介质细胞转移 (EndMT) 与大动脉动脉瘤疾病中的炎症性压力和内皮细胞功能障碍有关.
- 干白素-1 (IL-1) 信号通路是EndMT的关键调节者,并在实验性大动脉动脉瘤模型中发挥重要作用.
研究的目的:
- 为了调查EndMT在小鼠大动脉动脉瘤中的存在.
- 确定阻断IL-1信号是否可以减轻大动脉动脉瘤的发展.
主要方法:
- 在CDH5-Cre血统追踪小鼠中,使用前进性弹性酶治疗诱导了小鼠大动脉动脉瘤.
- 使用免疫组织化学和免疫光学分析了EndMT转录因子和细胞标记物.
- IL-1信号传递的作用在内皮特异性IL-1受体1淘汰赛小鼠和通过Anakinra的药理抑制进行了评估.
主要成果:
- 与对照组相比,弹性酶治疗显著增加了大动脉扩张.
- 遗传删除或药理抑制IL-1受体1明显减弱了大动脉扩张.
- 弹性酶诱导EndMT标记物,这些标记物通过IL-1受体1淘汰和Anakinra治疗而减少.
结论:
- 从内皮转移到介质细胞转移是大动脉动脉瘤疾病中的一个关键过程.
- 失去IL-1信号减弱了大动脉动脉瘤的发展.
- 准IL-1通路为大动脉动脉瘤疾病提供了潜在的治疗策略.
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