初潮时的年龄和与代谢功能障碍相关的脂肪肝疾病:来自中国西南地区大型人口流行病学研究的证据
Kehan Li1, Jianzhong Yin2, Zixiu Qin3
1Department of Health Behavior and Social Medicine, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Preventive medicine
|November 11, 2023
概括
初潮时的年龄较小增加了中国女性代谢功能障碍相关脂肪肝疾病 (MAFLD) 的风险. 成年早期的肥胖症部分介导了这一关联,强调了从年轻成年期开始预防肥胖的必要性.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
背景情况:
- 初潮时的年龄与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 之间的联系尚未得到充分证实.
- 研究这种关系对于了解女性肝脏健康至关重要.
研究的目的:
- 检查中国妇女初经年龄 (AAM) 和MAFLD之间的关联.
- 为了确定早期成年期肥胖是否调解了AAM-MAFLD关系.
主要方法:
- 对46873名中国女性 (30-79岁) 的横截面研究.
- 后勤回归模型评估了AAM和MAFLD的相关性.
- 调解分析探讨了成年早期肥胖的作用.
主要成果:
- 在AAM和MAFLD风险之间发现了线性反向关联.
- 较早的初潮 (例如,<12岁) 与14岁初潮相比,显著增加了MAFLD的几率.
- 成年早期的肥胖症部分调解了AAM和MAFLD之间的关联.
- 这种关联因年龄,种族和更年期而改变.
结论:
- 早期初潮是中国妇女MAFLD的危险因素.
- 针对年轻成年人的肥胖预防策略对于初潮早期的女性至关重要,以减轻MAFLD风险.
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