可修复的功能性和退行性 mitra 反的体外模型
Hayato Morimura1, Yusei Okamoto2, Jumpei Takada3
1Cooperative Major in Advanced Biomedical Sciences, Joint Graduate School of Tokyo Women's Medical University and Waseda University, Waseda University, Tokyo, Japan.
概括
研究人员开发了新的ex vivo模型来评估跨导管 mitra 门的修复. 这些功能性和退行性模型准确量化了额头肌吐 (MR) 和修复干预措施的影响,有助于设备开发.
科学领域:
- 心血管研究的心血管研究.
- 生物医学工程 生物医学工程
- 临床前研究 临床前研究
背景情况:
- 透导管 mitra 门修复是手术修复的新兴替代方案.
- 临床前研究对于评估跨导管中枢修复技术的有效性至关重要.
- 缺少已建立的对腹吐 (MR) 的活体模型.
研究的目的:
- 为了开发新的,可修复的外生模型,用于 mitra regurgitation.
- 在这些模型中量化评估反和干预措施的影响.
- 为了促进跨导管中枢门修复装置的临床前评估.
主要方法:
- 使用猪门开发功能性和退行性ex vivo部吐模型.
- 使用脉动的流动循环系统,并通过圆扩张或节切割控制反.
- 模型使用边缘到边缘或人工道技术进行修复.
主要成果:
- 功能性和退行性模型实现了分别为47.9%和58.5%的中度至重度反分数.
- 修复后的 mitra 反明显减少至 28.7% 和 26.0% (P < 0.001).
- 一个严重的功能模型显示,吐率为59.4%.
结论:
- 开发出来的功能和退行性模型可以产生足够的 mitrale 吐水平,以满足干预标准.
- 这些可复制,可维修的模型对于评估门维修程序和设备非常有价值.
- 控制反的能力增强了模型的多功能性,可能加速新型设备的开发.
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