FooDrugs:一个全面的食品药物相互作用数据库,包含文本文件和转录数据
Blanca Lacruz-Pleguezuelos, Oscar Piette1, Marco Garranzo1
1Computational Biology Group, Precision Nutrition and Cancer Research Program, IMDEA Food Institute, CEI UAM+CSIC, Carretera de Cantoblanco, 8, Madrid 28049, Spain.
Database : the journal of biological databases and curation
|November 11, 2023
概括
这项研究介绍了FooDrugs,这是一个关于食品药物相互作用 (FDI) 的全面数据库. FooDrugs集中了关键的知识,即食物如何影响药物的有效性和安全性,帮助临床实践.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物信息学是一种生物信息学.
- 药物发现 药物发现 药物发现
背景情况:
- 食品与药物相互作用 (FDI) 显著影响药物的有效性和安全性.
- 目前只有有限的资源可以全面记录外国直接投资.
- 了解FDI对于有效的临床实践和患者结果至关重要.
研究的目的:
- 开发和介绍FooDrugs,一个集中,可访问的食品药物相互作用知识数据库.
- 整合来自各种来源的外国直接投资信息,包括科学文献和分子数据.
- 为研究人员和临床医生提供研究和管理外国直接投资的宝贵资源.
主要方法:
- 使用自然语言处理 (NLP) 管道从科学文件和临床试验中提取潜在的外国直接投资.
- 一种分子相似性方法,比较由食物和药物诱导的基因表达变化,被用来推断额外的外国直接投资.
- 来自这两种不同的方法的数据整合形成了FooDrugs数据库的核心.
主要成果:
- FooDrugs数据库包含超过340万种潜在的食品药物相互作用.
- 从科学文献中通过NLP管道确定了大约110万名外国直接投资者.
- 通过分子相似性分析推断出超过230万个外国直接投资.
结论:
- FooDrugs提供了一个集中,免费和用户友好的潜在食品药物相互作用的存储库.
- 这个数据库增强了研究人员和临床医生对外国直接投资知识的可访问性.
- FooDrugs旨在改善在临床环境中对食品药物相互作用的理解和管理.
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