支气管过敏反应在患有阻塞性睡眠呼吸暂停与喘状症状的患者中的作用
Akiko Sano1, Takenori Kozuka2, Nanase Watatani1
1Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan.
概括
阻塞性睡眠呼吸暂停 (OSA) 与喘状症状显示出基于支气管过敏反应 (BHR) 的不同危险因素. 当BHR存在时,喘的严重程度可能决定OSA的严重程度.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 睡眠医学 睡眠医学
- 肺部病理学 肺部病理学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是喘的重要并发症和恶化的因素.
- 虽然肥胖和炎症与OSA-喘严重程度有关,但支气管过敏反应 (BHR) 的作用尚不清楚.
- 这项研究检查了与患有喘类症状的患者的OSA严重程度相关的BHR和中脂肪宽度.
研究的目的:
- 为了研究BHR,中脂肪宽度和OSA严重程度之间的关系.
- 为了确定OSA严重程度的风险因素是否根据患有喘类症状的患者的BHR存在或不存在而有所不同.
主要方法:
- 对患有喘症状的OSA患者进行回顾性分析,这些患者接受了BHR测试和胸部CT.
- 评估呼吸暂停 - 呼吸暂停指数 (AHI) 和PC20或前腹中脂肪宽度之间的相关性.
- 分析的分层根据BHR的存在或不存在.
主要成果:
- 与没有BHR的OSA患者相比,OSA患者的呼吸道阻塞,较低的兴奋值和较少的中间骨脂肪.
- 中脂肪宽度与整体AHI正相关,特别是在没有BHR的患者中.
- 在患有BHR的OSA患者中,在呼吸暂停指数和空气流量限制之间发现了负相关性,以及呼吸暂停指数和PC20.
结论:
- 较大的AHI的预测因子根据OSA患者的BHR状况而有所不同,这些患者具有类似喘的症状.
- 在BHR患者中,同时存在的喘的严重程度可能会影响OSA的严重程度.
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