缺25-基维生素D是外围T细胞淋巴瘤的较差预测因素
Hao-Rui Shen1,2,3, Jing Tang1,2,3, Wen-Yi Li1,2,3
1Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.
Annals of hematology
|November 11, 2023
概括
维生素D缺乏与外围T细胞淋巴瘤 (PTCL) 的较差结果有关. 将维生素D状态与T细胞淋巴瘤预后指数 (PIT) 结合起来,可以改善PTCL患者的生存预测.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 营养科学 营养科学
背景情况:
- 周围T细胞淋巴瘤 (PTCL) 是一种具有不良预后的侵袭性非霍奇金淋巴瘤.
- 维生素D,特别是25-氧维生素D (25-OH) D,在免疫功能中起作用,并可能影响癌症的结果.
研究的目的:
- 调查新诊断的PTCLs患者25-(OH) D缺乏症的预后意义.
- 评估是否结合25-OH) D状态可以改善现有的PTCL预后模型.
主要方法:
- 分析了156名新诊断的PTCL患者的队列.
- 使用单变量和多变量回归分析来确定无进展生存 (PFS) 和总生存 (OS) 的独立预后因素.
- 接收器运行特征 (ROC) 曲线评估了具有和没有25-OH) D状态的预后指数的准确性.
主要成果:
- 在PTCL患者中,25-(OH) D缺乏被确定为PFS和OS的独立不良预后因素 (P < 0.05).
- 这种关联在诸如血管免疫细胞T细胞淋巴瘤 (AITL) 和PTCL-not otherwise specified (PTCL-NOS) 等亚型中尤为明显.
- 在T细胞淋巴瘤 (PIT) 的预后指数中整合25-OH) D缺乏,与单独的PIT相比,显著提高了PFS和OS的预后准确性.
结论:
- 25-(OH) D 缺乏是PTCL中显著的负预后指标,影响患者的存活率.
- 在PTCL中,PIT和25-(OH) D状态的组合为风险分层和预后预测提供了更强大的工具.
- 对维生素D水平的临床考虑可能有助于优化PTCL患者的治疗策略和治疗结果.
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