在社会焦虑障碍中改变自我评估的一个大脑模型
Alec J Jamieson1, Ben J Harrison2, Rebekah Delahoy2
1Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia. alec.jamieson@unimelb.edu.au.
Translational psychiatry
|November 11, 2023
概括
社会焦虑障碍 (SAD) 在自我反思期间改变大脑网络动态. 患有SAD的个体在默认模式网络中表现出明显的连接性,特别是在考虑他人的观点时,影响自我评估和社会评估.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 默认模式网络 (DMN) 对于自我引用处理至关重要.
- 自参照处理中的功能障碍与心理健康状况有关,特别是社会焦虑障碍 (SAD).
研究的目的:
- 调查患有SAD个体的自我评估期间DMN动态的变化.
- 在特定的自我参考任务中,比较SAD患者和健康对照者之间的网络连接.
主要方法:
- 一项病例控制研究,涉及38名患有SAD的青少年和年轻成年人和72名健康对照.
- 功能性磁共振成像 (fMRI) 在直接和反射自我评估任务中.
- 动态因果建模 (DCM) 和参数实证贝叶斯分析DMN内的有效连接.
主要成果:
- SAD参与者在反射自我评估,而不是直接自我评估期间显示出改变的DMN连接性.
- 在SAD中,从后侧带带皮层 (PCC) 到中间前额皮层 (MPFC) 的刺激性连接性增加.
- 在反射自我评估过程中,在SAD中,从下顶叶 (IPL) 到MPFC的抑制连接性增加.
- 在SAD参与者中减少了PCC-MPFC和IPL-MPFC的内在连接,无论任务调制如何.
结论:
- 在反射自我评估和内在状态期间,SAD与MPFC的变异性 afferent连接有关.
- 反射自我评价中的连接性差异与SAD特征的负面社会评价的恐惧相一致.
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