尼尔马特里尔维尔/里托纳维尔和长期COVID症状的风险:一个回顾性队列研究
Seth Congdon1, Zev Narrowe2, Nang Yone2
1Department of Medicine, Montefiore Medical Center, 111 East 210th Street, Bronx, NY, 10467, USA. scongdon@montefiore.org.
Scientific reports
|November 11, 2023
概括
尼尔马特里尔维尔/里托纳维尔并没有降低成人SARS-CoV-2长期COVID的整体风险. 然而,这种抗病毒治疗与较少的脑雾和胸痛病例有关.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 长期COVID是一种复杂的疾病,具有多种症状,构成了重大的公共卫生挑战.
- 尼尔马特里尔维尔/里托纳维尔是一种用于治疗急性SARS-CoV-2感染的抗病毒药物.
- 尼尔马特里尔维尔/里托纳维尔对长期COVID发展的潜在影响仍在调查中.
研究的目的:
- 评估涅马特里尔维尔/里托纳维尔治疗与患长期COVID的风险之间的关联.
- 为了识别特定的长期COVID症状,可能会受到nirmatrelvir/ritonavir使用的影响.
主要方法:
- 一项对500名已确认感染SARS-CoV-2的成年人进行的回顾性队列研究.
- 长期COVID症状发展的比较250名接受尼尔马特里尔维尔/里托纳维尔和250名未接受的患者.
- 通过在感染后四个月的电话采访对11个预先规定的长期COVID症状的评估.
- 多变量后勤回归分析,调整人口统计和临床因素.
主要成果:
- 尼尔马特里尔维尔/里托纳维尔组 (44%) 和没有治疗组 (49.6%;p=0.21) 之间长期COVID的总体发病率没有显著差异.
- 涅玛特里尔维尔/里托纳维尔使用与脑雾 (OR 0.58) 和胸部疼痛/紧张 (OR 0.51) 的几率降低有关.
- 这些发现与之前的研究不同,这些研究仅依赖电子病历数据.
结论:
- 尼尔马特里尔维尔/里托纳维尔治疗与长期COVID的整体风险降低无关.
- 抗病毒药物可能对特定的长期COVID症状 (如脑雾和胸痛) 有好处.
- 需要进一步的研究来澄清尼尔马特里尔维尔/里托纳维尔在缓解长期COVID症状中的作用.
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