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使用不同的生理学基础的药理动力学建模平台对单克隆抗体处置预测的比较

Pieter-Jan De Sutter1, Elke Gasthuys2, An Vermeulen2

  • 1Laboratory of Medical Biochemistry and Clinical Analysis, Department of Bioanalysis, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium. pieterjan.desutter@ugent.be.

Journal of pharmacokinetics and pharmacodynamics
|November 11, 2023
PubMed
概括

基于生理学上的药理动力学 (PBPK) 模型显示了跨平台的类似单克隆抗体 (mAb) 血清预测. 然而,组织度预测有显著的差异,强调在模拟mAb组织配置时需要谨慎.

关键词:
这就是Adalimumab.生物分布 生物分布在IgG IgG的基础上.这就是Infliximab.单克隆抗体是一种单克隆抗体.基于生理学的药理动力学.

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