肝细胞癌中乳酸代谢表型的特征
Jiacheng Zhang1,2, Keshuai Dong1, Xin Zhang1,2
1Department of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, People's Republic of China.
Scientific reports
|November 11, 2023
概括
这项研究确定了肝细胞癌 (HCC) 中的关键乳酸代谢调节剂 (LAMR). 基于这些调节剂的新型风险评分有效预测患者的预后和对免疫治疗的反应.
科学领域:
- 在瘤学瘤学.
- 代谢学 代谢学 代谢学
- 生物信息学是一种生物信息学.
背景情况:
- 肝细胞癌 (HCC) 是一种异质癌症,需要改善预后标志物.
- 乳酸代谢对癌症的发展,转移和瘤微环境至关重要.
- 乳酸代谢调节剂 (LAMRs) 在HCC中的作用在很大程度上仍未被定义.
研究的目的:
- 研究LAMRs在HCC中的状态和预后意义.
- 开发HCC患者预测结果的预测风险得分.
- 探索风险得分与临床因素,突变和免疫治疗之间的关系.
主要方法:
- 基于HCC数据集中的LAMR的共识聚类.
- 集群之间的差异基因表达 (DEG) 分析.
- 风险评分构造的 LASSO 和 COX 回归.
- 在独立队列 (GSE14520) 中验证.
主要成果:
- 基于LAMR的共识聚类确定了基于LAMR的独特的HCC子组.
- 群体B表现出更高的免疫细胞透率,瘤微环境 (TME) 分数升高和更差的预后.
- 开发的风险评分有效预测了TCGA-LIHC和GSE14520队列的预后.
- 与临床特征,遗传突变,药物敏感性和免疫检查点抑制剂 (ICI) 疗效相关的风险得分.
结论:
- 乳酸代谢调节剂在HCC进展和患者预后方面发挥着重要作用.
- 新型风险评分为预测HCC结果提供了一种有价值的工具.
- 这些发现提供了对LAMRs对瘤微环境和免疫治疗反应的影响的见解.
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