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在不患糖尿病的肥胖症中,塞马格卢提德和心血管结果
A Michael Lincoff1, Kirstine Brown-Frandsen1, Helen M Colhoun1
1From the Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland (A.M.L.); Novo Nordisk, Søborg, Denmark (K.B.-F., S.E., S.H.-L., G.K.H., T.K.O., M.M.M., C.W.T.); the Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh (H.M.C.), and the National Institute for Cardiovascular Outcomes Research, University College London, London (J.D.) - both in the United Kingdom; the Department of Biostatistics, University of Washington (S.S.E.), and the Department of Medicine, VA Puget Sound Health Care System and University of Washington (S.E.K.) - both in Seattle; the Department of Vascular Medicine, Academic Medical Center, Amsterdam (G.K.H.); the Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago (R.F.K.); the Department of Internal Medicine (Endocrinology Division) and Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas (I.L.); the Department of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (J.P.); and Pennington Biomedical Research Center, Baton Rouge, LA (D.H.R.).
在没有糖尿病的超重或肥胖成年人中,塞马格卢提德显著降低了心血管事件. 这项研究表明,semaglutide.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 作为GLP-1受体激动剂的塞马格卢提德,已知可以减少糖尿病患者的心血管事件.
- 它对没有糖尿病的超重/肥胖个体的心血管风险的影响仍然未确立.
研究的目的:
- 调查塞马格卢提德在减轻超重或肥胖但没有糖尿病的患者心血管事件的疗效.
主要方法:
- 一个多中心,双盲,随机,安慰剂对照试验.
- 17,604名45岁以上的患有心血管疾病和BMI≥27 (没有糖尿病) 的患者每周接受皮下塞马格卢提德 (2.4毫克) 或安慰剂.
- 主要终点:心血管死亡,非致命的心肌梗塞或非致命中风的组合.
主要成果:
- 赛马格卢提德组:6.5%的患者经历了初级终点事件,而安慰剂组的这一比例为8.0% (HR 0.80;P<0.001).
- 副作用导致16.6%的塞马格卢提德组停止治疗,而安慰剂组的8.2%.
结论:
- 在没有糖尿病的超重/肥胖患者中,每周服用塞马格卢提德 (2.4毫克) 显著减少了主要的不良心血管事件.
- 这些发现支持塞马格卢提德在超出血糖控制的心血管风险降低中的作用.
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