在上衣细胞淋巴瘤患者中出现的二次恶性瘤
Kossi D Abalo1, Karin E Smedby2, Sara Ekberg3
1Department of Immunology, Genetics and Pathology, Cancer Precision Medicine, Uppsala University, Sweden; Department of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.
European journal of cancer (Oxford, England : 1990)
|November 12, 2023
概括
膜细胞淋巴瘤 (MCL) 幸存者面临着更高的二次恶性瘤 (SM) 风险. 用R-bendamustine治疗增加了这种风险,需要更安全,更有效的疗法来长期照顾MCL患者.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 癌症流行病学 癌症流行病学
背景情况:
- 膜细胞淋巴瘤 (MCL) 患者在现代治疗中经历了更长的缓解期,导致长期幸存者的数量越来越多.
- 对MCL幸存者的长期随访护理对于管理治疗相关的晚期影响至关重要,包括二次恶性瘤 (SM).
研究的目的:
- 为了调查二次恶性瘤 (SM) 的负担,在一个基于人群的队列上衣细胞淋巴瘤 (MCL) 患者.
- 为了比较MCL患者中MS的发病率与匹配的人口比较器.
主要方法:
- 一项以人口为基础的研究包括1,452名2000年至2017年期间在瑞典诊断出MCL患者,与13,992名比较者匹配.
- 使用安德森-吉尔方法分析了后续数据,以估计SM的危险比率 (HR),调整为相关共变量.
- 在MCL患者和对照者之间,以及在不同的初级治疗方案中,SM的发病率进行了比较.
主要成果:
- 与普通人群相比,MCL患者的SM发生率明显高 (HR_adj=1.6;95%CI:1.4-1.8).
- 在各种治疗组中观察到MS风险增加,与北欧-MCL2.2相比,R-bendamustine与明显更高的风险相关 (HR_adj=2.0;95%CI:1.3-3.2).
- 较高的MS风险与诊断时的年龄较大,男性性别和淋巴瘤家族病史有关. 黑色素瘤,其他皮肤瘤和淋巴细胞恶性瘤是常见的MSS.
结论:
- 膜细胞淋巴瘤幸存者表现出二次恶性瘤的风险较高.
- 选择的治疗方法,特别是R-bendamustine,显著影响了MCL患者中MS的风险.
- 开发新的治疗方案,平衡疗效与降低MS风险,对于改善长期MCL幸存者的结果至关重要.
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