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Updated: Aug 4, 2026

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity
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隔离和表征PR3特异性B细胞及其免疫球蛋白序列

Shane Kelly1, Katherine Jl Jackson1, Timothy J Peters1

  • 1Garvan Institute of Medical Research, UNSW Sydney, 384 Victoria Street, Darlinghurst, NSW, 2010, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, NSW, 2052, Australia.

Journal of autoimmunity
|November 12, 2023
PubMed
概括

研究人员发现了罕见的PR3特异性B细胞在患有多炎的粒状瘤病的患者中. 这些细胞对于诊断至关重要,表明B细胞早期发育参与PR3自我反应.

关键词:
带有多层炎的颗粒状.免疫球蛋白是一种免疫球蛋白.蛋白酶 3 蛋白质酶 3 的作用.血管炎是一种血管炎.

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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...