积极的精神分裂和运动冲动性与抑制控制期间腹部注意网络的响应偏差相关
Martina Vanova1, Ulrich Ettinger2, Luke Aldridge-Waddon3
1Centre for Cognitive and Clinical Neuroscience, College of Health, Medicine and Life Sciences, Brunel University London, London, United Kingdom; Division of Psychology, Department of Life Sciences, College of Health, Medicine and Life Sciences, Brunel University London, London, United Kingdom; Dementia Research Centre, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom.
概括
抑制性控制 (IC) 缺陷与精神病理特征有关. 诸如精神分裂和冲动性之类的特定特征与响应抑制任务期间不同的大脑活动模式相关.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 心理病理学 心理病理学
背景情况:
- 抑制控制 (IC) 中的异常与各种精神病理有关,包括精神分裂症谱和人格障碍.
- 反社会和暴力行为通常与CI受损有关.
研究的目的:
- 调查IC和精神病理特征之间的行为和神经关联.
- 检查精神分裂,精神病,冲动性和反应抑制之间的关系.
主要方法:
- 使用了一个新的Go/No-Go任务 (GNG) 与健康成年人的人类化身.
- 使用全脑功能磁共振成像 (fMRI) 来评估神经相关性.
- 使用牛津 - 利物浦感觉和经验库存 (O-LIFE) 和巴拉特冲动性量表 (BIS-11) 测量精神病理特征.
主要成果:
- 冲动性不符合性 (O-LIFE) 预测了GNG任务中的错误报警.
- 不寻常的体验 (O-LIFE) 和运动冲动性 (BIS-11) 预测了快速 GNG 试验中的敏感性.
- 在成功抑制期间,左舌环活动较低与较高的运动冲动性和不寻常经历有关.
- 较高的冲动性不合规性与响应抑制期间尾状核和前 cingulate 中的活动减少有关.
结论:
- 特定的精神病理特征,包括积极的精神分裂和冲动性,在响应抑制过程中显示出不同的神经激活模式.
- 这些发现突出了大脑注意力网络中抑制控制,精神分裂和冲动性之间的复杂相互作用.
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