在风湿性关节炎中,参与纤维细胞样同胞细胞功能的非编码RNA:从致病源到治疗
Yuwei Peng1, Meng Zhang1, Jiangkang Hu1
1Rheumatology and Immunology, PingXiangPeople's Hospital, No. 8, Wugongshangzhong Avenue, Anyuan District, PiangXiang City, Jiangxi Province, 337000, China.
Cytokine
|November 12, 2023
概括
非编码RNAs (ncRNAs) 在类风湿性关节炎 (RA) 中调节纤维细胞样同胞细胞 (FLS). 本综述详细介绍了ncRNA在FLS活动和RA病变发生中的作用,强调了治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 类风湿性关节炎 (RA) 是一种自身免疫性疾病,影响关节,并可能导致关节外表现.
- 纤维细胞样同胞细胞 (FLS) 是同胞体中的关键细胞,并与RA的发病有关.
- 在RA FLS中发现了调节失调的非编码RNA (ncRNA),这表明它们的调节作用.
研究的目的:
- 审查关于ncRNAs调节风湿性关节炎中FLS活动的文献.
- 在FLS中总结ncRNA介导的调节轴 (lncRNA/circRNA-miRNA-mRNA).
- 探索针对ncRNA治疗RA的治疗策略.
主要方法:
- 关于FLS和RA中ncRNAs的综合文献综述.
- 在FLS中分析涉及lncRNAs,circRNAs,miRNAs和mRNAs的调节网络.
- 检查在FLS中调节ncRNA的治疗干预措施.
主要成果:
- ncRNAs (miRNAs, lncRNAs, circRNAs) 是FLS功能的关键调节者,如增殖和细胞因子的产生.
- 特定的lncRNA/circRNA-miRNA-mRNA轴显著影响FLS活动和RA发展.
- 草药和外体显示出通过ncRNA调制调节FLS的潜力.
结论:
- ncRNAs在纤维细胞样同胞细胞功能和类风湿性关节炎的发病过程中发挥着关键作用.
- 在FLS中了解ncRNA调节网络,可以了解RA机制.
- 用草药和外体等药物向ncRNAs,为RA提供了一个有前途的治疗途径.
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