主要基因相容性复合体哈普洛类型与未接种疫苗和接种疫苗的牛对结核病的敏感性之间的关联
Anabel A Garcia1, Karren M Plain1, Peter C Thomson1
1Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Camden, NSW 2570, Australia.
Veterinary immunology and immunopathology
|November 12, 2023
概括
牛主要基因相容性复合体 (MHC) 的遗传变异影响了对Bovine Johne的抗性.
科学领域:
- 兽医免疫学 兽医免疫学
- 动物遗传学动物遗传学
- 牛群疾病 牛群疾病
背景情况:
- 牛牛约翰病 (BJD),是由Mycobacterium avium spp.引起的 甲状腺结核病 (MAP) 是一个严重的全球性问题在反动物.
- 遗传因素,特别是主要组织相容性复合体 (MHC) 内的遗传因素,可能在BJD耐药性中发挥作用.
- 标记器辅助选择可以通过利用免疫的遗传差异来帮助控制BJD.
研究的目的:
- 调查牛MHC基因与对牛约翰病的耐药性/易感性之间的关联.
- 分析疫苗接种和未接种牛群的MHC I和MHC II基因变异.
主要方法:
- 使用PCR对MHC I类和II类基因 (MHC I,MHC II) 中的多态区域进行测序.
- 在敏感和耐药牛群中确定MHC I和MHC II类型和等位基因的频率.
- 使用各种严格的病例定义来对暴露和感染进行分类动物.
主要成果:
- 在接种疫苗和未接种疫苗的牛群中,确定了特定的MHC I和MHC II单元类型和BJD耐药性/易感性之间的显著关联.
- 发现严格的案例定义增加了检测到的关联的强度和一致性.
- 几种MHC I和MHC II类型与耐药性有关,而其他类型与敏感性有关 (P <0.05).
结论:
- 牛中MHC遗传变异与牛约翰病耐药性有关.
- 利用MHC协会可以增强用于BJD控制的标记辅助选择策略.
- 标准化,严格的案例定义对于未来BJD遗传关联研究的可靠结果至关重要.
更多相关视频
06:57Author Spotlight: Adjuvant Activity of Mycobacterium paratuberculosis in Enhancing the Immunogenicity of Autoantigens During Experimental Autoimmune Encephalomyelitis
Published on: May 12, 2023
2.3K
11:17Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
Published on: March 10, 2021
6.4K
相关概念视频
Genome-wide Association Studies-GWAS
13.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.5K
Pulmonary Tuberculosis III
339
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
339
