多内佩西尔化物对COVID后记忆障碍的影响:一项随机对照试验
Parham Pooladgar1, Mehdi Sakhabakhsh2, Saeed Soleiman-Meigooni3
1Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
概括
与安慰剂相比,多尼佩西尔在COVID后综合征患者的整体记忆没有显著改善. 然而,该药物在特定的记忆子测试中显示出潜在的益处,这需要进一步调查认知功能障碍.
科学领域:
- 神经学 神经学
- 临床试验 临床试验
- 药理学 药理学是指药理学的学科.
背景情况:
- 后冠状病毒疾病 (COVID-19) 状况或后COVID综合征呈现持续的并发症,包括认知功能障碍和记忆障碍.
- 认知缺陷对受影响个体的执行功能和整体生活质量产生重大影响.
- 目前,对于COVID后的记忆障碍没有批准的治疗方法,需要进行临床研究.
研究的目的:
- 评估多尼佩西尔化物在治疗与后COVID综合征相关的记忆障碍方面的疗效.
- 为了在随机对照试验中比较多尼佩西尔化与安慰剂的影响.
主要方法:
- 一项随机对照试验,涉及25名被诊断患有COVID后记忆障碍的患者.
- 参与者被分配到多尼佩西尔化组 (n=10) 或对照组 (n=15).
- 记忆功能在基线,4周和12周时使用维克斯勒记忆量表修订 (WMS-R) 进行评估,并使用SPSS.R分析数据.
主要成果:
- 在4周和12周的多尼佩西尔和对照组之间没有观察到总体WMS-R子试验和指数得分的统计学上显著差异.
- 在多尼佩西尔组内,在视觉复制I和口头配对伴侣II子测试中发现了积极的趋势.
- 这些具体的改善表明,多尼佩西尔可能对某些记忆领域有针对性的作用.
结论:
- 在患有后COVID记忆障碍的患者中,donepezil 5 mg与对照组相比,在记忆尺度上没有显著的整体改善.
- 这些发现表明,多尼佩西尔可能为特定的记忆子测试提供好处,这表明它可能在管理认知功能障碍的某些方面发挥作用.
- 建议进行进一步的研究,以阐明确切的机制,并确认多尼佩西尔在COVID后与记忆缺陷有关的治疗潜力.
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