甘黄可以通过改变肠道微生物群和促进粘液细胞再生来缓解胃
Yufan Wu1, Yinglin Guo1, Tairun Huang2
1School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|November 12, 2023
概括
甘黄 (LF) 通过改善肠道细菌,增加有益的短链脂肪酸 (SCFA),并通过EGFR/ERK通路促进粘液产生和细胞再生,从而保护胃.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
背景情况:
- 来自Glycyrrhizae Radix et Rhizoma的甘黄 (LF) 显示出抗的活性.
- 在预防胃 (GU) 中,LF的精确机制需要进一步研究.
研究的目的:
- 阐明LF对乙醇诱导的胃的保护和再生机制.
- 研究LF对胃粘膜完整性,炎症,肠道微生物群和上皮细胞再生的影响.
主要方法:
- 在体外和体外 (老鼠) 评估LF对胃粘膜上皮细胞活力和乙醇诱导的损伤的影响.
- 对肠道微生物群组成和短链脂肪酸 (SCFA) 水平在LF治疗后的分析.
- 对粘液分泌,粘蛋白表达 (MUC5AC,MUC6) 和EGFR/ERK信号通路的评估.
主要成果:
- 在大鼠中,LF增强了胃粘膜上皮细胞活力,并减轻了乙醇诱导的胃损伤和炎症.
- 部分调节的LF肠道失调,增加SCFA度 (黄油酸,酸,酸).
- 乳腺炎上调胃粘液分泌和MUC5AC/MUC6表达,特别是叶中的MUC5AC,并激活EGFR/ERK通路,促进细胞再生.
结论:
- 乳腺癌通过抑制炎症,修复粘膜屏障和促进血管生成,对胃产生保护作用.
- 乳腺细胞调节肠道微生物群和SCFA代谢,促进粘液的产生,并通过EGFR/ERK通路激活增强上皮细胞的增殖.
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