与婴儿肺功能相关的空气污染暴露和与炎症相关的蛋白质的联合联系
Shizhen He1, Björn Lundberg2, Jenny Hallberg2
1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
International journal of hygiene and environmental health
|November 12, 2023
概括
婴儿肺功能可能会受到空气污染和与炎症相关的蛋白质特征异常的负面影响. 这些因素似乎在协同作用下相互作用,导致生命早期肺功能下降.
科学领域:
- 环境健康 环境健康
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
背景情况:
- 暴露于空气污染与不良呼吸道结果有关.
- 系统性炎症可能会调解空气污染对肺功能的影响.
- 婴儿对空气污染的敏感性可以通过与炎症相关的蛋白质来表征.
研究的目的:
- 研究空气污染暴露与与炎症相关的蛋白质之间的相互作用.
- 评估6个月大的婴儿对肺功能的影响.
主要方法:
- 使用了斯德哥尔摩的EMIL出生队列 (n=82).
- 测量了92种与炎症相关的蛋白质的血水平,并对婴儿进行了螺旋测量.
- 使用验证的分散模型对PM10,PM2.5和NO2的估计暴露.
主要成果:
- 发现颗粒物 (PM) 暴露和异常炎症概况与降低FEV0.5和FVC之间的联合关联.
- 在PM10中最小绝对偏差和IQR增加的0.1单位增加与FEV0.5和FVC的显著下降有关.
- 对于PM2.5也观察到类似的关联,但对NO2.2的关联较小.
结论:
- 早期暴露于空气污染和与炎症相关的蛋白质特征异常可能会协同损害婴儿肺功能.
- 研究结果强调了环境因素和生物标志物在婴儿呼吸系统健康中的联合作用.
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