与动脉样硬化和炎症相关的早期非酒精性脂肪肝疾病
1Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, China.
Clinics (Sao Paulo, Brazil)
|November 12, 2023
概括
非酒精性脂肪肝 (NAFLD) 与心血管风险增加有关,包括动脉样硬化. 在NAFLD患者的肝纤维化独立预测冠状动脉心脏病,炎症起着关键的调解作用.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一种多系统性疾病,与心血管疾病 (CVD) 有着显著的联系.
- 早期的NAFLD及其进展为肝纤维化越来越被认为是导致心血管并发症的潜在因素.
- 了解NAFLD,动脉样硬化和冠心病 (CHD) 之间的相互作用对于全面的患者管理至关重要.
研究的目的:
- 研究早期NAFLD和动脉样硬化之间的关联.
- 为了检查肝纤维化和冠心病 (CHD) 之间的相关性.
- 探索炎症机制在调解肝纤维化和心脏病之间的联系中的作用.
主要方法:
- 对607名接受冠状动脉计算机断层扫描血管学 (CCTA) 和腹部超声学 (US) 的患者进行了回顾性分析.
- 后勤回归用于评估NAFLD和动脉样硬化之间的关联.
- 调解分析用于评估炎症标志物在纤维化-心血管疾病关系中的作用.
主要成果:
- 在调整心血管风险因素后,NAFLD与动脉内脏厚和非化斑块有显著的相关性.
- 纤维化标志物 (FIB-4,APRI) 和炎症标志物 (NLR,SIRI) 独立与心脏病相关.
- 中性粒细胞与淋巴细胞的比率 (NLR) 完全介导了肝纤维化对心脏病的影响,在与传统风险因素相结合时,提高了预测准确度.
结论:
- NAFLD与亚临床动脉样硬化有关,表明心血管风险升高.
- 肝纤维化是早期NAFLD中CHD的独立预测因素.
- 炎症,特别是通过NLR,在NAFLD患者的CHD发展中发挥着重要的调解作用,突显了早期干预的必要性.
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