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在休息阶段服用莱博雷克桑 (lemborexant) 改善了2型糖尿病小鼠的睡眠和葡萄糖耐受性
Hiroshi Tsuneki1, Masanori Sugiyama2, Kiyofumi Sato2
1Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan; Department of Integrative Pharmacology, University of Toyama, Toyama, 930-0194, Japan.
European journal of pharmacology
|November 12, 2023
概括
睡眠辅助剂Lemborexant通过提高睡眠质量和增加清醒期间的体力活动,改善了糖尿病小鼠的葡萄糖耐受性. 这表明对管理2型糖尿病有潜在的益处.
科学领域:
- 内分泌学 在内分泌学.
- 睡眠医学 睡眠医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 睡眠障碍与肥胖和2型糖尿病有关.
- 伦博雷克桑 (Lemborexant) 是一种双素受体抗剂 (DORA),用于治疗失眠.
- 它对糖尿病患者的睡眠和葡萄糖代谢的影响尚不清楚.
研究的目的:
- 在2型糖尿病小鼠中研究勒博雷克桑特对睡眠和葡萄糖代谢的影响.
- 在db/db小鼠中评估lemborexant的影响,这些小鼠有睡眠障碍和葡萄糖不耐受.
主要方法:
- 在2型糖尿病db/db小鼠中,一次性和每日休息阶段的Lemborexant给药.
- 评估睡眠参数 (NREM,REM,唤醒情节).
- 评估葡萄糖耐受性,体重,胰岛素分泌和运动活动.
主要成果:
- 伦博雷克桑增加了NREM和REM睡眠的持续时间和插曲数量.
- 每日服用lemborexant可以改善糖尿病小鼠的葡萄糖耐受性,而不会改变体重或胰岛素分泌.
- 在饮食诱导的肥胖小鼠中观察到类似的葡萄糖耐受性改善,但在非糖尿病小鼠中没有.
- 糖尿病小鼠表现出增加的运动运动活动,没有行为异常.
结论:
- 兰博雷克桑特促进睡眠,并改善2型糖尿病模型中的葡萄糖代谢.
- 提高睡眠质量可以改善清醒和身体活动,有助于更好地控制葡萄糖.
- 莱博雷克桑提及时促进睡眠为2型糖尿病提供了潜在的治疗策略.
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