对COVID-19患者与Omicron变种肺炎严重性得分的比较
Naoyuki Miyashita1, Yasushi Nakamori2, Makoto Ogata1
1First Department of Internal Medicine, Division of Respiratory Medicine, Infectious Disease and Allergology, Kansai Medical University, Japan.
A-DROP评分系统有效地预测了COVID-19社区获得性肺炎 (CAP) 患者的死亡率. 它的性能与其他严重程度得分相美,证实了其临床实用性.
科学领域:
- 传染性疾病 传染性疾病
- 呼吸系统医学 呼吸系统医学
- 关键护理医学 关键护理医学
背景情况:
- 以前的研究证实了A-DROP得分与早期COVID-19变种死亡率之间的联系.
- 欧米克朗变种对COVID-19社区获得性肺炎 (CAP) 严重程度和死亡率的影响需要进一步调查.
研究的目的:
- 评估A-DROP评分系统在预测感染SARS-CoV-2 Omicron变种的COVID-19 CAP患者死亡率方面的有效性.
- 将A-DROP系统与肺炎严重性指数 (PSI) 和CURB-65得分进行比较,用于预测Omicron变种CAP的死亡率.
主要方法:
- 对547名COVID-19 CAP患者的分析,这些患者是由Omicron亚型 (BA.1,BA.2,BA.5) 引起的.
- 通过A-DROP系统定义的不同严重程度组的死亡率的评估.
- 使用接收器操作特征 (ROC) 分析对A-DROP,PSI和CURB-65进行比较,以预测30天死亡率.
主要成果:
- 在每个肺炎严重程度组内的Omicron亚型中均有相同的死亡率.
- 根据A-DROP (p < 0.001),随着疾病严重程度 (轻度至极度严重) 的增加,死亡率显著增加.
- A-DROP,PSI和CURB-65显示了30天死亡率的可比预测能力 (AUC值分别为0.881,0.879,0.863).
结论:
- A-DROP评分系统是预测由Omicron变种引起的COVID-19 CAP患者死亡率的一个有价值的工具.
- 在分层风险和指导临床管理方面,A-DROP系统表现强,类似于PSI和CURB-65.
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