捐赠人病毒性肝炎和肝脏移植
Sara-Catherine Whitney Zingg1, Kristina Lemon2
1Department of Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0558, Cincinnati, OH 45267, USA. Electronic address: https://twitter.com/transplant_u.
The Surgical clinics of North America
|November 12, 2023
概括
器官移植面临着短缺,导致使用来自型肝炎病毒 (HCV) 或乙型肝炎病毒 (HBV) 阳性供体的边缘肝脏全移植. 抗病毒疗法使得安全的移植成为可能,改善了这些重要器官的结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 移植医学 移植医学
- 传染性疾病 传染性疾病
背景情况:
- 肝移植中持续存在的器官短缺需要使用"边缘"的全移植.
- 型肝炎病毒 (HCV) 和乙型肝炎病毒 (HBV) 阳性捐赠者通常被认为是边际的.
- 抗病毒疗法的进步改变了器官移植的格局.
研究的目的:
- 为提供利用HCV阳性和HBV阳性肝脏全移植的当前做法和结果的概述.
- 突出直接作用抗病毒药物和核胺类同类药物对移植安全性和疗效的影响.
- 讨论在肝移植中使用活性病毒性供体全移植的可行性.
主要方法:
- 关于使用边缘性全移植进行肝移植的当前文献的综述.
- 与HCV和HBV阳性供体器官相关的结局分析.
- 评估抗病毒疗法在减轻风险方面的作用.
主要成果:
- 直接作用的抗病毒药物和核胺类同类药物可以安全地移植HCV和HBV阳性全移植.
- 移植和患者的存活率与传统的全移植相美.
- 使用活跃病毒性捐赠者全体移植显示出有希望的类似结果.
结论:
- 来自HCV和HBV阳性捐赠者的边缘异位移植是肝移植的越来越可行的选择.
- 抗病毒技术的进步显著扩大了供体库,改善了移植的可用性.
- 进一步研究和临床应用这些策略是有必要的,以解决器官短缺问题.
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